Gene

spi1a

ID

ZDB-GENE-060825-351

Name

Spi-1 proto-oncogene a

Symbol

spi1a Nomenclature History

Previous Names

spi1l (1)
zgc:152991

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in regulation of myeloid leukocyte differentiation. Predicted to localize to nucleus. Is expressed in anterior lateral plate mesoderm; intermediate cell mass of mesoderm; kidney; rostral blood island; and yolk. Orthologous to human SPI1 (Spi-1 proto-oncogene) and SPIB (Spi-B transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With spi1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
agammaglobulinemia 10	Alliance	Agammaglobulinemia 10, autosomal dominant	619707

Associated With spi1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000418	Ets domain
Family	IPR046328	ETS family
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily