Gene

trmt1

ID

ZDB-GENE-060810-40

Name

tRNA methyltransferase 1

Symbol

trmt1 Nomenclature History

Previous Names

im:7150454 (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have tRNA (guanine-N2-)-methyltransferase activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Is expressed in several structures, including head; immature eye; mesoderm; midbrain; and neural plate. Orthologous to human TRMT1 (tRNA methyltransferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7150454 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trmt1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 68	Alliance	Intellectual developmental disorder, autosomal recessive 68	618302

Associated With trmt1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000571	Zinc finger, CCCH-type
Family	IPR002905	tRNA methyltransferase, Trm1
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
Homologous_superfamily	IPR036855	Zinc finger, CCCH-type superfamily
Homologous_superfamily	IPR042296	tRNA methyltransferase, Trm1, C-terminal

Domain Details Per Protein

Protein	Length	S-adenosyl-L-methionine-dependent methyltransferase superfamily	tRNA methyltransferase, Trm1	tRNA methyltransferase, Trm1, C-terminal	Zinc finger, CCCH-type	Zinc finger, CCCH-type superfamily
UniProtKB:A0A8M3B710 InterPro	629
UniProtKB:F1QGD9 InterPro	672

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	trmt1-201 (1) Ensembl	Ensembl		2,733 nt	Select Tool
ncRNA	trmt1-002 (1) Ensembl	Ensembl		847 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations