Gene
scube3
- ID
- ZDB-GENE-060717-1
- Name
- signal peptide, CUB domain, EGF-like 3
- Symbol
- scube3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity. Involved in skeletal muscle fiber development and smoothened signaling pathway. Predicted to localize to cell surface and extracellular space. Is expressed in several structures, including blastomere; central nervous system; optic cup; segmental plate; and solid lens vesicle. Orthologous to human SCUBE3 (signal peptide, CUB domain and EGF like domain containing 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tsao et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2 | Alliance | Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies | 619184 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000859 | CUB domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011641 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| Domain | IPR024731 | EGF domain |
| Domain | IPR026823 | Complement Clr-like EGF domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR052071 | Signal peptide, CUB and EGF-like domain-containing protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Length | Complement Clr-like EGF domain | CUB domain | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | NOTCH1 EGF-like calcium-binding domain | Signal peptide, CUB and EGF-like domain-containing protein | Spermadhesin, CUB domain superfamily | Tyrosine-protein kinase ephrin type A/B receptor-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R0I7
|
995 | ||||||||||||
|
UniProtKB:A0A8M9PKI0
|
1019 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance