Gene
itgav
- ID
- ZDB-GENE-060616-382
- Name
- integrin, alpha V
- Symbol
- itgav Nomenclature History
- Previous Names
-
- zgc:136222 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Involved in several processes, including Kupffer's vesicle development; axis elongation involved in somitogenesis; and cell migration involved in gastrulation. Localizes to integrin complex. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Is expressed in several structures, including axis; diencephalon; head; pleuroperitoneal region; and post-vent vasculature. Orthologous to human ITGAV (integrin subunit alpha V).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
Domain | IPR013649 | Integrin alpha, first immunoglubulin-like domain |
Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
Domain | IPR048286 | Integrin alpha, third immunoglobulin-like domain |
Family | IPR000413 | Integrin alpha chain |
Homologous_superfamily | IPR028994 | Integrin alpha, N-terminal |
Homologous_superfamily | IPR032695 | Integrin domain superfamily |
Repeat | IPR013517 | FG-GAP repeat |
Repeat | IPR013519 | Integrin alpha beta-propellor |
Domain Details Per Protein
Protein | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha chain, C-terminal cytoplasmic region, conserved site | Integrin alpha, first immunoglubulin-like domain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin alpha, third immunoglobulin-like domain | Integrin domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q3LTM3
|
1045 |
Interactions and Pathways
No data available
Plasmids
No data available