Gene

npr3

ID

ZDB-GENE-060531-91

Name

natriuretic peptide receptor 3

Symbol

npr3 Nomenclature History

Previous Names

im:7138418
si:dkey-199l1.2 (1)
zgc:158440

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable natriuretic peptide receptor activity and peptide hormone binding activity. Acts upstream of or within cardiac muscle cell proliferation. Predicted to be located in membrane. Is expressed in several structures, including heart; hypochord; nervous system; neural tube; and renal system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7138418 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Becker et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With npr3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Boudin-Mortier syndrome	619543

Associated With npr3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001828	Receptor, ligand binding region
Family	IPR001170	Adenylyl cyclase class-4/guanylyl cyclase
Family	IPR052612	Atrial Natriuretic Peptide Clearance Receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I