Gene

prkg2

ID
ZDB-GENE-060531-80
Name
protein kinase cGMP-dependent 2
Symbol
prkg2 Nomenclature History
Previous Names
  • si:dkey-18e17.2 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to be involved in protein phosphorylation. Is expressed in integument; nervous system; and pleuroperitoneal region. Orthologous to human PRKG2 (protein kinase cGMP-dependent 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Li et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkg2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acromesomelic dysplasia-4 Alliance Acromesomelic dysplasia 4 619636
Spondylometaphyseal dysplasia, Pagnamenta type 619638
Associated With prkg2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR018488 Cyclic nucleotide-binding, conserved site
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR035014 cGMP-dependent protein kinase, catalytic domain
Family IPR002374 cGMP-dependent kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal cGMP-dependent kinase cGMP-dependent protein kinase, catalytic domain Cyclic nucleotide-binding, conserved site Cyclic nucleotide-binding domain Cyclic nucleotide-binding domain superfamily Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily RmlC-like jelly roll fold Serine/threonine-protein kinase, active site
UniProtKB:A0A8M9Q2S7 769
UniProtKB:A2AVJ3 768
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prkg2-201 (1) Ensembl 2,307 nt
mRNA prkg2-202 (1) Ensembl 2,526 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations