Gene

myo1ha

ID

ZDB-GENE-060531-78

Name

myosin IHa

Symbol

myo1ha Nomenclature History

Previous Names

si:dkey-189p24.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within cranial skeletal system development. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. Is expressed in brain; mandibular arch skeleton; neuromast; otic sensory epithelium; and pharyngeal arch. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human MYO1H (myosin IH).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Sun et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo1ha Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Central hypoventilation syndrome, congenital, 2, and autonomic dysfunction	619482

Associated With myo1ha Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR010926	Class I myosin tail homology domain
Domain	IPR036072	Class I myosin, motor domain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Class I myosin, motor domain	Class I myosin tail homology domain	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9QEJ0 InterPro	1039
UniProtKB:A0A8M3B9I7 InterPro	1059

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	myo1ha-201 (1) Ensembl	Ensembl		2,973 nt	Select Tool ZFIN BLAST
mRNA	myo1ha-202 (1) Ensembl	Ensembl		3,083 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations