Gene
lrrc8ab
- ID
- ZDB-GENE-060531-43
- Name
- leucine rich repeat containing 8 VRAC subunit Ab
- Symbol
- lrrc8ab Nomenclature History
- Previous Names
-
- si:ch211-236k19.7
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to several human genes including LRRC8A (leucine rich repeat containing 8 VRAC subunit A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Tseng et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Tseng et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| agammaglobulinemia 5 | Alliance | ?Agammaglobulinemia 5 | 613506 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Leucine-rich repeat | Leucine-rich repeat domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | LRRC8, pannexin-like TM region |
|---|---|---|---|---|---|---|
|
UniProtKB:A2BF98
|
796 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lrrc8ab-201
(1)
|
Ensembl | 7,828 nt | ||
| mRNA |
lrrc8ab-202
(1)
|
Ensembl | 2,717 nt |
Interactions and Pathways
No data available
Plasmids
No data available