Gene
pcsk5a
- ID
- ZDB-GENE-060531-130
- Name
- proprotein convertase subtilisin/kexin type 5a
- Symbol
- pcsk5a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have serine-type endopeptidase activity. Involved in anterior lateral line development and neuromast development. Predicted to localize to integral component of Golgi membrane and trans-Golgi network. Is expressed in several structures, including eye; lateral line system; liver; otic vesicle; and pleuroperitoneal region. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chitramuthu et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022398 | Peptidase S8, subtilisin, His-active site |
| Active_site | IPR023827 | Peptidase S8, subtilisin, Asp-active site |
| Active_site | IPR023828 | Peptidase S8, subtilisin, Ser-active site |
| Domain | IPR000209 | Peptidase S8/S53 domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001368 | TNFR/NGFR cysteine-rich region |
| Domain | IPR002884 | P domain |
| Domain | IPR032778 | Growth factor receptor domain 4 |
| Domain | IPR032815 | Peptidase S8, pro-domain |
| Domain | IPR034182 | Kexin/furin catalytic domain |
| Family | IPR015500 | Peptidase S8, subtilisin-related |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036852 | Peptidase S8/S53 domain superfamily |
| Homologous_superfamily | IPR038466 | Peptidase S8, pro-domain superfamily |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Length | EGF-like domain | Furin-like repeat | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Kexin/furin catalytic domain | P domain | Peptidase S8, pro-domain | Peptidase S8, pro-domain superfamily | Peptidase S8/S53 domain | Peptidase S8/S53 domain superfamily | Peptidase S8, subtilisin, Asp-active site | Peptidase S8, subtilisin, His-active site | Peptidase S8, subtilisin-related | Peptidase S8, subtilisin, Ser-active site | TNFR/NGFR cysteine-rich region |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q4U3
|
1867 | ||||||||||||||||
|
UniProtKB:A0A8M1RIN1
|
1867 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcsk5a-201
(1)
|
Ensembl | 5,466 nt | ||
| mRNA |
pcsk5a-202
(1)
|
Ensembl | 3,495 nt |
Interactions and Pathways
No data available
Plasmids
No data available