Gene

mov10b.2

ID

ZDB-GENE-060526-371

Name

Mov10 RNA helicase b, tandem duplicate 2

Symbol

mov10b.2 Nomenclature History

Previous Names

si:dkeyp-38g6.3

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have RNA binding activity. Predicted to be involved in mRNA cleavage involved in gene silencing by miRNA. Predicted to localize to P granule; P-body; and cytosol. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human MOV10 (Mov10 RISC complex RNA helicase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Yang et al., 2022

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mov10b.2 Human Ortholog

No data available

Associated With mov10b.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR026122	Helicase MOV-10/SDE3, DEXXQ/H-box helicase domain
Domain	IPR041677	DNA2/NAM7 helicase, helicase domain
Domain	IPR041679	DNA2/NAM7 helicase-like, C-terminal
Domain	IPR047187	Upf1-like, C-terminal helicase domain
Domain	IPR049075	Helicase MOV-10, N-terminal
Domain	IPR049077	Helicase MOV-10, Ig-like domain
Domain	IPR049079	Helicase MOV-10, helical domain
Domain	IPR049080	Helicase MOV-10-like, beta-barrel domain
Family	IPR045055	DNA2/NAM7-like helicase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	DNA2/NAM7 helicase, helicase domain	DNA2/NAM7 helicase-like, C-terminal	DNA2/NAM7-like helicase	Helicase MOV-10, helical domain	Helicase MOV-10, Ig-like domain	Helicase MOV-10-like, beta-barrel domain	Helicase MOV-10, N-terminal	Helicase MOV-10/SDE3, DEXXQ/H-box helicase domain	P-loop containing nucleoside triphosphate hydrolase	Upf1-like, C-terminal helicase domain
UniProtKB:Q1LXK5 InterPro	1015

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	mov10b.2-201 (1) Ensembl	Ensembl		3,131 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: mov10b.1 and mov10b.2 appear to be the result of a tandem duplication with sequence identity and conserved synteny to human MOV10 and mouse Mov10. Zebrafish mov10a is the genome duplicate of the ancestral mov10b gene.

Citations