Gene

idua

ID

ZDB-GENE-060526-29

Name

alpha-L-iduronidase

Symbol

idua Nomenclature History

Previous Names

si:ch211-12e13.9 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have L-iduronidase activity. Predicted to be involved in carbohydrate metabolic process. Human ortholog(s) of this gene implicated in Scheie syndrome; mucopolysaccharidosis I; mucopolysaccharidosis Ih; and mucopolysaccharidosis Ih/s. Orthologous to human IDUA (alpha-L-iduronidase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With idua Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mucopolysaccharidosis Ih	Alliance	Mucopolysaccharidosis Ih	607014
mucopolysaccharidosis Ih/s	Alliance	Mucopolysaccharidosis Ih/s	607015
Scheie syndrome	Alliance	Mucopolysaccharidosis Is	607016

Associated With idua Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR049165	Glycosyl hydrolases family 39, active site
Domain	IPR049166	Glycosyl hydrolases family 39, N-terminal catalytic domain
Domain	IPR049167	Alpha-L-iduronidase, C-terminal domain
Family	IPR000514	Glycoside hydrolase, family 39
Family	IPR051923	Glycosyl Hydrolase Family 39
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR017853	Glycoside hydrolase superfamily

Domain Details Per Protein

Protein	Length	Alpha-L-iduronidase, C-terminal domain	Glycoside hydrolase, family 39	Glycoside hydrolase superfamily	Glycosyl Hydrolase Family 39	Glycosyl hydrolases family 39, active site	Glycosyl hydrolases family 39, N-terminal catalytic domain	Immunoglobulin-like fold
UniProtKB:A0A8M9PQU4 InterPro	637
UniProtKB:A2ARH2 InterPro	637
UniProtKB:A0A8M9PRM9 InterPro	637

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	idua-201 (1) Ensembl	Ensembl		3,693 nt	Select Tool
mRNA	idua-202 (1) Ensembl	Ensembl		2,717 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations