Gene

slc4a4a

ID

ZDB-GENE-060526-274

Name

solute carrier family 4 member 4a

Symbol

slc4a4a Nomenclature History

Previous Names

slc4a4
id:ibd2520
NBC1 (1)
NBCe1 (1)
si:dkey-256m11.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Exhibits sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport and regulation of intracellular pH. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in renal tubular acidosis. Is expressed in several structures, including central nervous system; eye; intermediate mesoderm; optic cup; and pleuroperitoneal region. Orthologous to human SLC4A4 (solute carrier family 4 member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

24 figures from 17 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Sussman et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc4a4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Proximal renal tubular acidosis-ocular anomaly syndrome	604278

Associated With slc4a4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011531	Bicarbonate transporter-like, transmembrane domain
Domain	IPR013769	Band 3 cytoplasmic domain
Family	IPR003020	Bicarbonate transporter, eukaryotic
Family	IPR003024	Sodium bicarbonate cotransporter
Homologous_superfamily	IPR016152	Phosphotransferase/anion transporter

Domain Details Per Protein

Protein	Length	Band 3 cytoplasmic domain	Bicarbonate transporter, eukaryotic	Bicarbonate transporter-like, transmembrane domain	Phosphotransferase/anion transporter	Sodium bicarbonate cotransporter
UniProtKB:Q3ZMH2 InterPro	1082
UniProtKB:A0A2R8QD45 InterPro	1073
UniProtKB:A0A8M3ASQ6 InterPro	1146
UniProtKB:A0A8M3B2R8 InterPro	1114
UniProtKB:A0A8M3AZV9 InterPro	1105
UniProtKB:A0A8M9Q3P6 InterPro	1114

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	slc4a4a-201 (1) Ensembl	Ensembl	6,227 nt	Select Tool ZFIN BLAST
mRNA	slc4a4a-202 (1) Ensembl	Ensembl	2,810 nt	Select Tool
mRNA	slc4a4a-205 (1) Ensembl	Ensembl	6,323 nt	Select Tool ZFIN BLAST
mRNA	slc4a4a-206 (1) Ensembl	Ensembl	3,417 nt	Select Tool ZFIN BLAST
ncRNA	slc4a4a-002 (1) Ensembl	Ensembl	499 nt	Select Tool
ncRNA	slc4a4a-003 (1) Ensembl	Ensembl	542 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations