Gene

phldb1a

ID

ZDB-GENE-060526-272

Name

pleckstrin homology-like domain, family B, member 1a

Symbol

phldb1a Nomenclature History

Previous Names

phldb1
si:dkey-252h13.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to be involved in regulation of microtubule cytoskeleton organization. Predicted to be active in basal cortex. Human ortholog(s) of this gene implicated in osteogenesis imperfecta. Orthologous to human PHLDB1 (pleckstrin homology like domain family B member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With phldb1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Osteogenesis imperfecta, type XXIII	620639

Associated With phldb1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000253	Forkhead-associated (FHA) domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR037810	PHLDB1/2/3, PH domain
Family	IPR052212	Pleckstrin homology-like domain-containing protein
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily

Domain Details Per Protein

Protein	Length	Forkhead-associated (FHA) domain	PHLDB1/2/3, PH domain	PH-like domain superfamily	Pleckstrin homology domain	Pleckstrin homology-like domain-containing protein	SMAD/FHA domain superfamily
UniProtKB:A0A8M9Q9E5 InterPro	1424
UniProtKB:A0A8M9PL23 InterPro	1382
UniProtKB:A0A8M3ASG1 InterPro	1226
UniProtKB:A0A8M9Q464 InterPro	1334
UniProtKB:A0A8M3B9Q8 InterPro	1417
UniProtKB:A0A8M3ASK7 InterPro	1385
UniProtKB:A0A8M3B2L8 InterPro	1294
UniProtKB:A0A8N7TEA5 InterPro	1425
UniProtKB:A0A2R8QUX6 InterPro	1290
UniProtKB:A0A8M9PYP5 InterPro	1374

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	phldb1a-201 (1) Ensembl	Ensembl	3,725 nt	Select Tool ZFIN BLAST
mRNA	phldb1a-202 (1) Ensembl	Ensembl	4,244 nt	Select Tool ZFIN BLAST
mRNA	phldb1a-203 (1) Ensembl	Ensembl	5,123 nt	Select Tool ZFIN BLAST
mRNA	phldb1a-204 (1) Ensembl	Ensembl	4,511 nt	Select Tool ZFIN BLAST
mRNA	phldb1a-205 (1) Ensembl	Ensembl	5,252 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations