Gene

tmc2b

ID

ZDB-GENE-060526-262

Name

transmembrane channel-like 2b

Symbol

tmc2b Nomenclature History

Previous Names

si:dkey-229d2.2

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have mechanosensitive ion channel activity. Involved in detection of mechanical stimulus involved in sensory perception of sound; inner ear morphogenesis; and neuromast development. Predicted to localize to integral component of plasma membrane. Is expressed in inner ear; neuromast; and neuromast hair cell. Orthologous to human TMC2 (transmembrane channel like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tmc2b Human Ortholog

No data available

Associated With tmc2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR012496	TMC domain
Family	IPR038900	Transmembrane channel-like protein

Domain Details Per Protein

Protein	Length	TMC domain	Transmembrane channel-like protein
UniProtKB:F1QZE9 InterPro	892
UniProtKB:A0A8M6YZ60 InterPro	955

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tmc2b-201 (1) Ensembl	Ensembl		2,679 nt	Select Tool ZFIN BLAST
mRNA	tmc2b-202 (1) Ensembl	Ensembl		2,359 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations