Gene
tmc1
- ID
- ZDB-GENE-060526-261
- Name
- transmembrane channel-like 1
- Symbol
- tmc1 Nomenclature History
- Previous Names
-
- si:dkey-229d2.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have mechanosensitive ion channel activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound. Localizes to stereocilium bundle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Is expressed in anterior crista; inner ear; lateral crista; neuromast; and posterior crista. Orthologous to human TMC1 (transmembrane channel like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Maeda et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhu et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 36 | Alliance | Deafness, autosomal dominant 36 | 606705 |
| autosomal recessive nonsyndromic deafness 7 | Alliance | Deafness, autosomal recessive 7 | 600974 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TMC domain | Transmembrane channel-like protein |
|---|---|---|---|
|
UniProtKB:F1QFU0
|
720 | ||
|
UniProtKB:A0A5H1ZRH9
|
990 | ||
|
UniProtKB:A0A8M9PKH1
|
990 |
Interactions and Pathways
No data available
Plasmids
No data available