Gene
nlgn3b
- ID
- ZDB-GENE-060526-197
- Name
- neuroligin 3b
- Symbol
- nlgn3b Nomenclature History
- Previous Names
-
- nlgn3a (1)
- si:dkey-125i10.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to act upstream of or within cell adhesion and synapse organization. Predicted to be located in cell junction and plasma membrane. Predicted to be active in cell surface and postsynaptic specialization membrane. Is expressed in several structures, including digestive system; gonad; heart; nervous system; and swim bladder. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to human NLGN3 (neuroligin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Autism susceptibility, X-linked 1} | 300425 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Alpha/Beta hydrolase fold | Carboxylesterase, type B | Neuroligin | Neuroligin and Bile salt-activated lipase |
|---|---|---|---|---|---|
|
UniProtKB:A2BHL9
|
846 | ||||
|
UniProtKB:D0EVX2
|
845 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nlgn3b-201
(1)
|
Ensembl | 4,438 nt |
Interactions and Pathways
No data available
Plasmids
No data available