Gene

sec14l8

ID

ZDB-GENE-060526-180

Name

SEC14-like lipid binding 8

Symbol

sec14l8 Nomenclature History

Previous Names

si:ch211-89f7.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Exhibits GTP binding activity; GTPase activating protein binding activity; and GTPase activity. Involved in Wnt signaling pathway, calcium modulating pathway; positive regulation of epiboly involved in gastrulation with mouth forming second; and regulation of convergent extension involved in axis elongation. Localizes to extrinsic component of plasma membrane. Is expressed in blastomere; posterior cardinal vein; trunk vasculature; vascular cord; and vasculature. Orthologous to several human genes including SEC14L2 (SEC14 like lipid binding 2) and SEC14L3 (SEC14 like lipid binding 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sec14l8 Human Ortholog

No data available

Associated With sec14l8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001251	CRAL-TRIO lipid binding domain
Domain	IPR009038	GOLD domain
Domain	IPR011074	CRAL/TRIO, N-terminal domain
Family	IPR051064	SEC14-like and CRAL-TRIO domain-containing protein
Homologous_superfamily	IPR036273	CRAL/TRIO, N-terminal domain superfamily
Homologous_superfamily	IPR036598	GOLD domain superfamily
Homologous_superfamily	IPR036865	CRAL-TRIO lipid binding domain superfamily