Gene

srgap3

ID
ZDB-GENE-060524-4
Name
SLIT-ROBO Rho GTPase activating protein 3
Symbol
srgap3 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have Rac GTPase binding activity. Predicted to be involved in negative regulation of cell migration. Predicted to localize to cytoplasm. Orthologous to human SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Zheng et al., 2022
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from van Dam et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With srgap3 Human Ortholog
No data available
Associated With srgap3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000198 Rho GTPase-activating protein domain
Domain IPR001060 FCH domain
Domain IPR001452 SH3 domain
Domain IPR031160 F-BAR domain
Domain IPR035648 srGAP1/2/3, SH3 domain
Family IPR051627 SLIT-ROBO Rho GTPase-activating
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR027267 AH/BAR domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Domain Details Per Protein
Protein Length AH/BAR domain superfamily F-BAR domain FCH domain Rho GTPase-activating protein domain Rho GTPase activation protein SH3 domain SH3-like domain superfamily SLIT-ROBO Rho GTPase-activating srGAP1/2/3, SH3 domain
UniProtKB:A0A0R4IAE2 1094
UniProtKB:E7EYC8 1070
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA srgap3-201 (1) Ensembl 5,100 nt
mRNA srgap3-205 (1) Ensembl 4,197 nt
ncRNA srgap3-002 (1) Ensembl 881 nt
ncRNA srgap3-003 (1) Ensembl 468 nt
ncRNA srgap3-004 (1) Ensembl 539 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations