Gene

cpt1aa

ID

ZDB-GENE-060503-925

Name

carnitine palmitoyltransferase 1Aa (liver)

Symbol

cpt1aa Nomenclature History

Previous Names

cpt1a
si:dkey-56p7.8

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have carnitine O-palmitoyltransferase activity. Involved in lymphangiogenesis and regulation of fatty acid beta-oxidation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Is expressed in liver and male organism. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

27 figures from 24 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cpt1aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
carnitine palmitoyltransferase I deficiency	Alliance	CPT deficiency, hepatic, type IA	255120

Associated With cpt1aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR032476	Carnitine O-palmitoyltransferase, N-terminal
Domain	IPR039551	Choline/carnitine acyltransferase domain
Family	IPR000542	Acyltransferase ChoActase/COT/CPT
Homologous_superfamily	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily
Homologous_superfamily	IPR042231	Choline/Carnitine o-acyltransferase, domain 2

Domain Details Per Protein

Protein	Length	Acyltransferase ChoActase/COT/CPT	Carnitine O-palmitoyltransferase, N-terminal	Chloramphenicol acetyltransferase-like domain superfamily	Choline/carnitine acyltransferase domain	Choline/Carnitine o-acyltransferase, domain 2
UniProtKB:A0A0R4ILW3 InterPro
UniProtKB:Q1MTA9 InterPro	773
UniProtKB:A0A8M1N9G1 InterPro	774

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cpt1aa-201 (1) Ensembl	Ensembl	2,325 nt	Select Tool
mRNA	cpt1aa-202 (1) Ensembl	Ensembl	3,354 nt	Select Tool
mRNA	cpt1aa-203 (1) Ensembl	Ensembl	440 nt	Select Tool
mRNA	cpt1aa-204 (1) Ensembl	Ensembl	2,574 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations