Gene
cdk6
- ID
- ZDB-GENE-060503-786
- Name
- cyclin dependent kinase 6
- Symbol
- cdk6 Nomenclature History
- Previous Names
-
- si:ch211-234f14.1
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; malignant glioma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Is expressed in brain; gill; gonad; kidney; and retina. Orthologous to human CDK6 (cyclin dependent kinase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Webster et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 12 | Alliance | ?Microcephaly 12, primary, autosomal recessive | 616080 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR028788 | Cyclin-dependent kinase 6 |
| Family | IPR050108 | Cyclin-dependent kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Cyclin-dependent kinase | Cyclin-dependent kinase 6 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:I3IT74
|
324 | ||||||
|
UniProtKB:E9QFH2
|
302 |
Interactions and Pathways
No data available
Plasmids
No data available