Gene

si:ch211-225p5.8

ID
ZDB-GENE-060503-783
Name
si:ch211-225p5.8
Symbol
si:ch211-225p5.8 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have ion channel binding activity and sodium channel inhibitor activity. Predicted to be involved in cardiac muscle cell action potential involved in contraction; regulation of heart rate by cardiac conduction; and regulation of sodium ion transmembrane transporter activity. Predicted to localize to voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 5; early infantile epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2008
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With si:ch211-225p5.8 Human Ortholog
No data available
Associated With si:ch211-225p5.8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003599 Immunoglobulin domain subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013106 Immunoglobulin V-set domain
Family IPR027098 Sodium channel subunit beta-1/beta-3
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin domain subtype Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin V-set domain Sodium channel subunit beta-1/beta-3
UniProtKB:A8E7Q8 220
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA si:ch211-225p5.8-201 (1) Ensembl 3,619 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations