Gene

exosc5

ID

ZDB-GENE-060503-675

Name

exosome component 5

Symbol

exosc5 Nomenclature History

Previous Names

si:ch211-194n6.2
zgc:153707

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Acts upstream of or within brain development. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Predicted to be active in nucleolus. Orthologous to human EXOSC5 (exosome component 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Cabrera-Quio et al., 2021

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Slavotinek et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With exosc5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cerebellar ataxia, brain abnormalities, and cardiac conduction defects	619576

Associated With exosc5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001247	Exoribonuclease, phosphorolytic domain 1
Domain	IPR015847	Exoribonuclease, phosphorolytic domain 2
Family	IPR050080	Ribonuclease PH
Homologous_superfamily	IPR020568	Ribosomal protein uS5 domain 2-type superfamily
Homologous_superfamily	IPR027408	PNPase/RNase PH domain superfamily
Homologous_superfamily	IPR036345	Exoribonuclease, PH domain 2 superfamily