Gene

fhod3a

ID

ZDB-GENE-060503-633

Name

formin homology 2 domain containing 3a

Symbol

fhod3a Nomenclature History

Previous Names

si:dkey-263h23.7 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity. Predicted to be involved in cardiac myofibril assembly; cortical actin cytoskeleton organization; and sarcomere organization. Predicted to act upstream of or within regulation of stress fiber assembly. Predicted to be active in cytoplasm and cytoskeleton. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human FHOD3 (formin homology 2 domain containing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fhod3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cardiomyopathy, familial hypertrophic, 28	619402

Associated With fhod3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR014767	Diaphanous autoregulatory (DAD) domain
Domain	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Domain	IPR015425	Formin, FH2 domain
Domain	IPR041387	FHOD1, N-terminal GTPase-binding domain
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR042201	Formin, FH2 domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	Diaphanous autoregulatory (DAD) domain	FHOD1, N-terminal GTPase-binding domain	Formin, FH2 domain	Formin, FH2 domain superfamily	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
UniProtKB:A0A8M9PNT9 InterPro	1557
UniProtKB:A0A8M9P251 InterPro	1549
UniProtKB:A0A8M9PS41 InterPro	1415
UniProtKB:A0A8M9PGU1 InterPro	1509
UniProtKB:A0A8M9PB98 InterPro	1520

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fhod3a-201 (1) Ensembl	Ensembl	3,813 nt	Select Tool ZFIN BLAST
mRNA	fhod3a-202 (1) Ensembl	Ensembl	7,052 nt	Select Tool ZFIN BLAST
mRNA	fhod3a-203 (1) Ensembl	Ensembl	3,780 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations