Gene
vars2
- ID
- ZDB-GENE-060503-575
- Name
- valyl-tRNA synthetase 2, mitochondrial
- Symbol
- vars2 Nomenclature History
- Previous Names
-
- si:ch211-152p11.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Kayvanpour et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 20 | Alliance | Combined oxidative phosphorylation deficiency 20 | 615917 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR002300 | Aminoacyl-tRNA synthetase, class Ia |
| Domain | IPR013155 | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding |
| Domain | IPR033705 | Valyl tRNA synthetase, anticodon-binding domain |
| Family | IPR002303 | Valine-tRNA ligase |
| Homologous_superfamily | IPR009008 | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ia | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Aminoacyl-tRNA synthetase, class I, conserved site | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | Rossmann-like alpha/beta/alpha sandwich fold | Valine-tRNA ligase | Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain | Valyl tRNA synthetase, anticodon-binding domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DIT4
|
1057 |
Interactions and Pathways
No data available
Plasmids
No data available