Gene

gabbr1b

ID

ZDB-GENE-060503-5

Name

gamma-aminobutyric acid (GABA) B receptor, 1b

Symbol

gabbr1b Nomenclature History

Previous Names

gabbr1.2 (1)
hbog (1)
humphrey bogart (1)
si:ch211-127d20.2

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have G protein-coupled GABA receptor activity. Involved in behavioral response to nicotine. Predicted to localize to G protein-coupled receptor heterodimeric complex. Is expressed in central nervous system; eye; female organism; and male organism. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gabbr1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with language delay and variable cognitive abnormalities	620502

Associated With gabbr1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000436	Sushi/SCR/CCP domain
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR017978	GPCR family 3, C-terminal
Family	IPR002455	GPCR family 3, GABA-B receptor
Family	IPR002456	GPCR family 3, gamma-aminobutyric acid receptor, type B1
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I
Homologous_superfamily	IPR035976	Sushi/SCR/CCP superfamily

Domain Details Per Protein

Protein	Length	GPCR family 3, C-terminal	GPCR family 3, GABA-B receptor	GPCR family 3, gamma-aminobutyric acid receptor, type B1	Periplasmic binding protein-like I	Receptor, ligand binding region	Sushi/SCR/CCP domain	Sushi/SCR/CCP superfamily
UniProtKB:F1QAJ3 InterPro	993
UniProtKB:A0A8M2BHH0 InterPro	994

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	gabbr1b-201 (1) Ensembl	Ensembl		3,446 nt	Select Tool ZFIN BLAST
mRNA	gabbr1b-202 (1) Ensembl	Ensembl		3,766 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations