Gene
dyrk1b
- ID
- ZDB-GENE-060503-499
- Name
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
- Symbol
- dyrk1b Nomenclature History
- Previous Names
-
- si:ch211-225p5.1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within endoderm formation. Predicted to be active in nucleus. Is expressed in head and somite. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Mazmanian et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Mazmanian et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| abdominal obesity-metabolic syndrome 3 | Alliance | Abdominal obesity-metabolic syndrome 3 | 615812 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR044131 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain |
| Family | IPR050494 | Serine/threonine and dual-specificity kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine and dual-specificity kinase | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B4L1
|
826 | ||||||
|
UniProtKB:A0A0R4II39
|
681 | ||||||
|
UniProtKB:D1L3Y5
|
751 | ||||||
|
UniProtKB:A0A8M2B533
|
833 | ||||||
|
UniProtKB:A0A8M2B4K6
|
758 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dyrk1b-201
(1)
|
Ensembl | 4,382 nt | ||
| mRNA |
dyrk1b-203
(1)
|
Ensembl | 3,933 nt | ||
| ncRNA |
dyrk1b-002
(1)
|
Ensembl | 918 nt |
Interactions and Pathways
No data available
Plasmids