Gene

prf1.3

ID

ZDB-GENE-060503-461

Name

perforin 1.3

Symbol

prf1.3 Nomenclature History

Previous Names

prf19b (1)
si:dkey-89b17.6

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Predicted to be involved in cytolysis. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Is expressed in gill; kidney; and kidney cell. Orthologous to human PRF1 (perforin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Varela et al., 2016

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prf1.3 Human Ortholog

No data available

Associated With prf1.3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020863	Membrane attack complex component/perforin domain, conserved site
Domain	IPR000008	C2 domain
Domain	IPR020864	Membrane attack complex component/perforin (MACPF) domain
Domain	IPR037300	Perforin-1, C2 domain
Family	IPR052784	Perforin-1 pore-forming
Homologous_superfamily	IPR035892	C2 domain superfamily