Gene
ptpn22
- ID
- ZDB-GENE-060503-458
- Name
- protein tyrosine phosphatase non-receptor type 22
- Symbol
- ptpn22 Nomenclature History
- Previous Names
-
- si:dkey-78k11.1
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within heart development. Predicted to be active in cytoplasm and nucleus. Is expressed in heart and heart tube. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); graft-versus-host disease; and pulmonary tuberculosis. Orthologous to several human genes including PTPN22 (protein tyrosine phosphatase non-receptor type 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ma et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| rheumatoid arthritis | Alliance | {Rheumatoid arthritis, susceptibility to} | 180300 |
| systemic lupus erythematosus | Alliance | {Systemic lupus erythematosus susceptibility to} | 152700 |
| type 1 diabetes mellitus | Alliance | {Diabetes, type 1, susceptibility to} | 222100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Family | IPR047170 | Tyrosine-protein phosphatase non-receptor type 12/18/22 |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
| Protein | Length | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Tyrosine-protein phosphatase non-receptor type 12/18/22 | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B909
|
886 | ||||||
|
UniProtKB:A5D6T3
|
887 | ||||||
|
UniProtKB:A0A8M2B913
|
882 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn22-201
(1)
|
Ensembl | 2,664 nt | ||
| mRNA |
ptpn22-202
(1)
|
Ensembl | 585 nt |
Interactions and Pathways
No data available
Plasmids
No data available