Gene

ago3b

ID

ZDB-GENE-060503-452

Name

argonaute RISC catalytic component 3b

Symbol

ago3b Nomenclature History

Previous Names

Ago3b (1)
eif2c3
eif2c3b
sb:eu332
si:dkey-3n22.3

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have endoribonuclease activity, cleaving miRNA-paired mRNA. Predicted to be involved in mRNA catabolic process and miRNA mediated inhibition of translation. Predicted to localize to P-body and RISC complex. Is expressed in several structures, including eye; fin; integument; pleuroperitoneal region; and somite. Orthologous to human AGO3 (argonaute RISC catalytic component 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu332 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ago3b Human Ortholog

No data available

Associated With ago3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003100	PAZ domain
Domain	IPR003165	Piwi domain
Domain	IPR014811	Argonaute, linker 1 domain
Domain	IPR032472	Argonaute linker 2 domain
Domain	IPR032473	Protein argonaute, Mid domain
Domain	IPR032474	Protein argonaute, N-terminal
Domain	IPR045246	Argonaute-like, PIWI domain
Family	IPR028603	Protein argonaute-3
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR036085	PAZ domain superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily

Domain Details Per Protein

Protein	Length	Argonaute-like, PIWI domain	Argonaute, linker 1 domain	Argonaute linker 2 domain	PAZ domain	PAZ domain superfamily	Piwi domain	Protein argonaute-3	Protein argonaute, Mid domain	Protein argonaute, N-terminal	Ribonuclease H-like superfamily	Ribonuclease H superfamily
UniProtKB:A3KPK0 InterPro	860
UniProtKB:A0A8M3AVD2 InterPro	476
UniProtKB:K4IKE9 InterPro	867

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ago3b-201 (1) Ensembl	Ensembl	4,368 nt	Select Tool ZFIN BLAST
mRNA	ago3b-203 (1) Ensembl	Ensembl	3,301 nt	Select Tool ZFIN BLAST
ncRNA	ago3b-002 (1) Ensembl	Ensembl	670 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations