Gene
calcr
- ID
- ZDB-GENE-060503-420
- Name
- calcitonin receptor
- Symbol
- calcr Nomenclature History
- Previous Names
-
- CTR (1)
- si:ch211-77k19.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable calcitonin receptor activity. Predicted to contribute to amylin receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including eye; gill; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (calcitonin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Lafont et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteoporosis | Alliance | {Osteoporosis, postmenopausal, susceptibility} | 166710 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR003287 | GPCR, family 2, calcitonin receptor family |
| Family | IPR050332 | G-protein coupled receptor 2 |
| Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
Domain Details Per Protein
| Protein | Length | GPCR, family 2, calcitonin receptor family | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PPS1
|
598 |
Interactions and Pathways
No data available
Plasmids
No data available