Gene
sema4ab
- ID
- ZDB-GENE-060503-363
- Name
- sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
- Symbol
- sema4ab Nomenclature History
- Previous Names
-
- si:dkey-78d16.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including negative regulation of axon extension involved in axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to localize to extracellular space and integral component of plasma membrane. Human ortholog(s) of this gene implicated in cone-rod dystrophy 10 and retinitis pigmentosa 35. Orthologous to human SEMA4A (semaphorin 4A) and SEMA4B (semaphorin 4B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cone-rod dystrophy 10 | Alliance | Cone-rod dystrophy 10 | 610283 |
| retinitis pigmentosa 35 | Alliance | Retinitis pigmentosa 35 | 610282 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001627 | Sema domain |
| Domain | IPR016201 | PSI domain |
| Domain | IPR045791 | Semaphorin 4F, C-terminal |
| Family | IPR027231 | Semaphorin |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036352 | Sema domain superfamily |
| Repeat | IPR002165 | Plexin repeat |
Domain Details Per Protein
| Protein | Length | Immunoglobulin-like fold | Plexin repeat | PSI domain | Sema domain | Sema domain superfamily | Semaphorin | Semaphorin 4F, C-terminal | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BHW0
|
836 | ||||||||
|
UniProtKB:F1R501
|
831 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema4ab-201
(1)
|
Ensembl | 6,640 nt | ||
| mRNA |
sema4ab-202
(1)
|
Ensembl | 5,411 nt |
Interactions and Pathways
No data available
Plasmids
No data available