Gene
ipo8
- ID
- ZDB-GENE-060503-3
- Name
- importin 8
- Symbol
- ipo8 Nomenclature History
- Previous Names
-
- si:ch211-116i17.1
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable small GTPase binding activity. Acts upstream of or within dorsal/ventral pattern formation; positive regulation of BMP signaling pathway; and regulation of fertilization. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol and nuclear envelope. Is expressed in blastomere. Orthologous to human IPO8 (importin 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Mbarek et al., 2023
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| VISS syndrome | 619472 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | Exportin-2, central domain | Importin-beta, N-terminal domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PUE9
|
992 | ||||
|
UniProtKB:A0A8M3B1K0
|
658 | ||||
|
UniProtKB:A0A8M3ARG6
|
661 | ||||
|
UniProtKB:A0A2R8RMT5
|
1018 | ||||
|
UniProtKB:B7ZV68
|
1015 |
Interactions and Pathways
No data available
Plasmids
No data available