Gene

hecw1b

ID

ZDB-GENE-060503-2

Name

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b

Symbol

hecw1b Nomenclature History

Previous Names

hecw1
nedl1 (1)
si:ch211-106n13.1

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Predicted to localize to cytoplasm. Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hecw1b Human Ortholog

No data available

Associated With hecw1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR000569	HECT domain
Domain	IPR001202	WW domain
Domain	IPR032348	E3 ubiquitin-protein ligase HECW1/2, N-terminal
Domain	IPR037795	E3 ubiquitin-protein ligase HECW, C2 domain
Domain	IPR040524	E3 ubiquitin-protein ligase HECW1, helical box domain
Family	IPR050409	E3 ubiquitin-protein ligase
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR036020	WW domain superfamily