Gene
nfixb
- ID
- ZDB-GENE-060421-5000
- Name
- nuclear factor I/Xb
- Symbol
- nfixb Nomenclature History
- Previous Names
-
- zgc:136878
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA replication and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in dorsal telencephalon; midbrain; muscle; and telencephalon. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome 2. Orthologous to human NFIX (nuclear factor I X).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Marshall-Smith syndrome | Alliance | Marshall-Smith syndrome | 602535 |
| Sotos syndrome 2 | Alliance | Malan syndrome | 614753 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019739 | CTF transcription factor/nuclear factor 1, conserved site |
| Domain | IPR003619 | MAD homology 1, Dwarfin-type |
| Domain | IPR019548 | CTF transcription factor/nuclear factor 1, N-terminal |
| Domain | IPR020604 | CTF transcription factor/nuclear factor 1, DNA-binding domain |
| Family | IPR000647 | CTF transcription factor/nuclear factor 1 |
Domain Details Per Protein
Interactions and Pathways
No data available
Plasmids
No data available