Gene
nfixb
- ID
- ZDB-GENE-060421-5000
- Name
- nuclear factor I/Xb
- Symbol
- nfixb Nomenclature History
- Previous Names
-
- zgc:136878
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA replication and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in dorsal telencephalon; midbrain; muscle; and telencephalon. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome 2. Orthologous to human NFIX (nuclear factor I X).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Marshall-Smith syndrome | Alliance | Marshall-Smith syndrome | 602535 |
Sotos syndrome 2 | Alliance | Malan syndrome | 614753 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019739 | CTF transcription factor/nuclear factor 1, conserved site |
Domain | IPR003619 | MAD homology 1, Dwarfin-type |
Domain | IPR019548 | CTF transcription factor/nuclear factor 1, N-terminal |
Domain | IPR020604 | CTF transcription factor/nuclear factor 1, DNA-binding domain |
Family | IPR000647 | CTF transcription factor/nuclear factor 1 |
Domain Details Per Protein
Protein | Additional Resources | Length | CTF transcription factor/nuclear factor 1 | CTF transcription factor/nuclear factor 1, conserved site | CTF transcription factor/nuclear factor 1, DNA-binding domain | CTF transcription factor/nuclear factor 1, N-terminal | MAD homology 1, Dwarfin-type |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3B860 | InterPro | 562 | |||||
UniProtKB:Q1RLS5 | InterPro | 440 | |||||
UniProtKB:A0A8M2BAY5 | InterPro | 528 | |||||
UniProtKB:A0A8M3AXV2 | InterPro | 530 | |||||
UniProtKB:A0A8M3AQD9 | InterPro | 513 | |||||
UniProtKB:A0A8M3AQR1 | InterPro | 556 | |||||
UniProtKB:A0A8M2BBB5 | InterPro | 536 | |||||
UniProtKB:A0A8M3AQR5 | InterPro | 561 | |||||
UniProtKB:A0A8M3B0T9 | InterPro | 500 | |||||
UniProtKB:A0A8M3B863 | InterPro | 512 | |||||
UniProtKB:A0A8M3AXU6 | InterPro | 574 | |||||
UniProtKB:A0A8M3AQD4 | InterPro | 573 | |||||
UniProtKB:A0A8M3B0T6 | InterPro | 531 |
Interactions and Pathways
No data available
Plasmids
No data available