Gene

mpl

ID

ZDB-GENE-060421-1

Name

MPL proto-oncogene, thrombopoietin receptor

Symbol

mpl Nomenclature History

Previous Names

c-mpl (1)
mpll
tpor (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have nucleic acid binding activity. Involved in thrombocyte differentiation. Predicted to localize to integral component of membrane. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Is expressed in blood; nucleate erythrocyte; thrombocyte; and ventral wall of dorsal aorta. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mpl Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital amegakaryocytic thrombocytopenia	Alliance	Amegakaryocytic thrombocytopenia, congenital, 1	604498
essential thrombocythemia	Alliance	Thrombocythemia 2	601977
myelofibrosis	Alliance	Myelofibrosis with myeloid metaplasia, somatic	254450

Associated With mpl Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital amegakaryocytic thrombocytopenia	mpl^sm10/sm10; sm9Tg	standard conditions	Lin et al., 2017
congenital amegakaryocytic thrombocytopenia	mpl^sm10/sm10; la2Tg	standard conditions	Lin et al., 2017
congenital amegakaryocytic thrombocytopenia	mpl^sm10/sm10 (AB)	standard conditions	Lin et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003961	Fibronectin type III
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR015152	Growth hormone/erythropoietin receptor, ligand binding
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Growth hormone/erythropoietin receptor, ligand binding	Immunoglobulin-like fold	Zinc finger C2H2-type
UniProtKB:A0A8M2BDQ1 InterPro	641
UniProtKB:Q6EIY6 InterPro	614

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mpl-201 (1) Ensembl	Ensembl	1,968 nt	Select Tool ZFIN BLAST
mRNA	mpl-202 (1) Ensembl	Ensembl	2,175 nt	Select Tool
mRNA	mpl-203 (1) Ensembl	Ensembl	1,840 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations