Gene
smtla
- ID
- ZDB-GENE-060123-2
- Name
- somatolactin alpha
- Symbol
- smtla Nomenclature History
- Previous Names
-
- sla
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable growth hormone activity and growth hormone receptor binding activity. Predicted to be involved in several processes, including growth hormone receptor signaling pathway; positive regulation of receptor signaling pathway via JAK-STAT; and response to nutrient levels. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in head; hypophysis; and pars intermedia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease of endocrine system (multiple); diabetic retinopathy; isolated growth hormone deficiency (multiple); and progeria. Orthologous to human CSHL1 (chorionic somatomammotropin hormone like 1); GH1 (growth hormone 1); and GH2 (growth hormone 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Somatotropin hormone, conserved site | Somatotropin/prolactin |
|---|---|---|---|---|---|
| UniProtKB:Q330L3 | InterPro | 233 | |||
| UniProtKB:A0A8M9PFJ9 | InterPro | 250 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available