Gene

lhx2b

ID

ZDB-GENE-051220-1

Name

LIM homeobox 2b

Symbol

lhx2b Nomenclature History

Previous Names

lhx2
bel
belladonna
zgc:152707

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including camera-type eye development; nervous system development; and optomotor response. Predicted to localize to nucleus. Used to study congenital nystagmus and pathologic nystagmus. Is expressed in several structures, including brain; forebrain neural keel; forebrain neural rod; optic vesicle; and retina. Orthologous to human LHX2 (LIM homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 10 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lhx2b Human Ortholog

No data available

Associated With lhx2b Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital nystagmus	lhx2b^tv42z/tv42z	standard conditions	Huang et al., 2006
congenital nystagmus	lhx2b^tv42z/tv42z	standard conditions	(3)
pathologic nystagmus	lhx2b^tv42z/tv42z	control	Bögli et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR001781	Zinc finger, LIM-type
Family	IPR050453	LIM/homeobox transcription factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily