Gene
wnt7aa
- ID
- ZDB-GENE-051129-1
- Name
- wingless-type MMTV integration site family, member 7Aa
- Symbol
- wnt7aa Nomenclature History
- Previous Names
-
- wnt7a
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; neuron differentiation; and positive regulation of JNK cascade. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; head; otic vesicle; pectoral fin bud; and spinal cord. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fuhrmann syndrome | Alliance | Fuhrmann syndrome | 228930 |
| Schinzel type phocomelia | Alliance | Ulna and fibula, absence of, with severe limb deficiency | 276820 |
| ?Santos syndrome | 613005 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Wnt | Wnt-7 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:Q4JLT0
|
349 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
wnt7aa-201
(1)
|
Ensembl | 3,435 nt |
Interactions and Pathways
No data available
Plasmids
No data available