Gene
nedd4l
- ID
- ZDB-GENE-051118-2
- Name
- NEDD4 like E3 ubiquitin protein ligase
- Symbol
- nedd4l Nomenclature History
- Previous Names
-
- nedd4b (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable sodium channel inhibitor activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Bakkers et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Periventricular nodular heterotopia 7 | 617201 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR000569 | HECT domain |
| Domain | IPR001202 | WW domain |
| Family | IPR024928 | E3 ubiquitin-protein ligase, SMURF1 type |
| Family | IPR050409 | E3 ubiquitin-protein ligase |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
Domain Details Per Protein
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nedd4l-201
(1)
|
Ensembl | 3,033 nt | ||
| mRNA |
nedd4l-202
(1)
|
Ensembl | 4,936 nt | ||
| mRNA |
nedd4l-203
(1)
|
Ensembl | 2,964 nt |
Interactions and Pathways
No data available
Plasmids
No data available