Gene
drd4-rs
- ID
- ZDB-GENE-051113-172
- Name
- dopamine receptor D4 related sequence
- Symbol
- drd4-rs Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in G protein-coupled receptor signaling pathway; negative regulation of cytosolic calcium ion concentration; and negative regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within adenylate cyclase-inhibiting dopamine receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adenohypophyseal placode; central nervous system; otic vesicle; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (dopamine receptor D4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dopamine D4 receptor | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:Q32PM9
|
418 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
drd4-rs-201
(1)
|
Ensembl | 1,716 nt | ||
| mRNA |
drd4-rs-202
(1)
|
Ensembl | 6,292 nt |
Interactions and Pathways
No data available
Plasmids
No data available