Gene

gamt

ID

ZDB-GENE-051030-97

Name

guanidinoacetate N-methyltransferase

Symbol

gamt Nomenclature History

Previous Names

zgc:123136

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have guanidinoacetate N-methyltransferase activity. Predicted to be involved in creatine biosynthetic process. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and guanidinoacetate methyltransferase deficiency. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and yolk. Orthologous to human GAMT (guanidinoacetate N-methyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gamt Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
guanidinoacetate methyltransferase deficiency	Alliance	Cerebral creatine deficiency syndrome 2	612736

Associated With gamt Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR026480	Arginine N-methyltransferase 2-like domain
Family	IPR016550	Guanidinoacetate N-methyltransferase
Family	IPR051038	RMT2/GAMT Methyltransferase
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily