Gene
rab27a
- ID
- ZDB-GENE-050913-46
- Name
- RAB27A, member RAS oncogene family
- Symbol
- rab27a Nomenclature History
- Previous Names
-
- zgc:114135 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have GTPase activity. Predicted to be involved in several processes, including Rab protein signal transduction; melanosome transport; and positive regulation of exocytosis. Predicted to localize to melanosome and secretory granule. Human ortholog(s) of this gene implicated in Griscelli syndrome type 2 and non-Langerhans-cell histiocytosis. Is expressed in cloaca; nervous system; and pronephric tubule. Orthologous to human RAB27A (RAB27A, member RAS oncogene family).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Griscelli syndrome type 2 | Alliance | Griscelli syndrome, type 2 | 607624 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Rab27a/b | Small GTPase | Small GTPase superfamily, Rab | Small GTP-binding domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q4V8U8
|
222 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rab27a-201
(1)
|
Ensembl | 1,474 nt |
Interactions and Pathways
No data available
Plasmids