Gene
rab27a
- ID
- ZDB-GENE-050913-46
- Name
- RAB27A, member RAS oncogene family
- Symbol
- rab27a Nomenclature History
- Previous Names
-
- zgc:114135 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in exocytosis and positive regulation of exocytosis. Predicted to be located in late endosome and membrane. Predicted to be active in Golgi apparatus; apical plasma membrane; and cytoplasmic vesicle. Is expressed in cloaca; nervous system; and pronephric tubule. Human ortholog(s) of this gene implicated in Griscelli syndrome type 2 and non-Langerhans-cell histiocytosis. Orthologous to human RAB27A (RAB27A, member RAS oncogene family).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Griscelli syndrome type 2 | Alliance | Griscelli syndrome, type 2 | 607624 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Rab27a/b | Small GTPase | Small GTPase superfamily, Rab | Small GTP-binding domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q4V8U8
|
222 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rab27a-201
(1)
|
Ensembl | 1,474 nt |
Interactions and Pathways
No data available
Plasmids