Gene
recql
- ID
- ZDB-GENE-050809-134
- Name
- RecQ helicase-like
- Symbol
- recql Nomenclature History
- Previous Names
-
- zgc:110631 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have 3'-5' DNA helicase activity; annealing helicase activity; and four-way junction helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via homologous recombination. Predicted to localize to chromosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Is expressed in basal plate midbrain region; central nervous system; and presumptive diencephalon. Orthologous to human RECQL (RecQ like helicase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7162021 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| RECON progeroid syndrome | 620370 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR018982 | RQC domain |
| Domain | IPR032284 | ATP-dependent DNA helicase RecQ, zinc-binding domain |
| Family | IPR004589 | DNA helicase, ATP-dependent, RecQ type |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | ATP-dependent DNA helicase RecQ, zinc-binding domain | DEAD/DEAH box helicase domain | DNA helicase, ATP-dependent, RecQ type | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RQC domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q498Z7
|
639 | ||||||||
|
UniProtKB:A0A8M9PHB7
|
798 |
Interactions and Pathways
No data available
Plasmids
No data available