Gene
recql
- ID
- ZDB-GENE-050809-134
- Name
- RecQ helicase-like
- Symbol
- recql Nomenclature History
- Previous Names
-
- zgc:110631 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable 3'-5' DNA helicase activity and four-way junction helicase activity. Predicted to be involved in DNA replication and double-strand break repair via homologous recombination. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be located in nucleus. Predicted to be active in chromosome and cytoplasm. Is expressed in basal plate midbrain region; central nervous system; and presumptive diencephalon. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Orthologous to human RECQL (RecQ like helicase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7162021 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| RECON progeroid syndrome | 620370 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR018982 | RQC domain |
| Domain | IPR032284 | ATP-dependent DNA helicase RecQ, zinc-binding domain |
| Family | IPR004589 | DNA helicase, ATP-dependent, RecQ type |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-dependent DNA helicase RecQ, zinc-binding domain | DEAD/DEAH box helicase domain | DNA helicase, ATP-dependent, RecQ type | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RQC domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q498Z7 | InterPro | 639 | ||||||||
| UniProtKB:A0A8M9PHB7 | InterPro | 798 |
Interactions and Pathways
No data available
Plasmids
No data available