Gene

nsfb

ID

ZDB-GENE-050808-1

Name

N-ethylmaleimide-sensitive factor b

Symbol

nsfb Nomenclature History

Previous Names

unm_au13
unm_au18

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have ATPase activity. Involved in pigment granule maturation and retinal pigment epithelium development. Predicted to localize to Golgi stack. Used to study oculocutaneous albinism. Is expressed in several structures, including nervous system; otic vesicle; pectoral fin; pectoral fin bud; and swim bladder. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nsfb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 96	Alliance	Developmental and epileptic encephalopathy 96	619340

Associated With nsfb Via Experimental Models

Human Disease	Fish	Conditions	Citations
oculocutaneous albinism	nsfb^au13/au13	standard conditions	Hanovice et al., 2015
oculocutaneous albinism	nsfb^au18/au18 (AB)	standard conditions	Hanovice et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003338	CDC48, N-terminal subdomain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR004201	CDC48, domain 2
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Domain	IPR054419	NSF, AAA+ ATPase lid domain
Family	IPR039812	Vesicle-fusing ATPase
Homologous_superfamily	IPR009010	Aspartate decarboxylase-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029067	CDC48 domain 2-like superfamily

Domain Details Per Protein

Protein	Length	AAA ATPase, AAA+ lid domain	AAA+ ATPase domain	Aspartate decarboxylase-like domain superfamily	ATPase, AAA-type, conserved site	ATPase, AAA-type, core	CDC48, domain 2	CDC48 domain 2-like superfamily	CDC48, N-terminal subdomain	NSF, AAA+ ATPase lid domain	P-loop containing nucleoside triphosphate hydrolase	Vesicle-fusing ATPase
UniProtKB:A0A8M6Z3H7 InterPro	653
UniProtKB:Q4U0S6 InterPro	747
UniProtKB:F1QGG3 InterPro	747

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nsfb-201 (1) Ensembl	Ensembl	2,353 nt	Select Tool
mRNA	nsfb-203 (1) Ensembl	Ensembl	3,466 nt	Select Tool
mRNA	nsfb-204 (1) Ensembl	Ensembl	2,723 nt	Select Tool ZFIN BLAST
ncRNA	nsfb-003 (1) Ensembl	Ensembl	281 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations