Gene

trmu

ID

ZDB-GENE-050522-540

Name

tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase

Symbol

trmu Nomenclature History

Previous Names

mut1 (1)
zgc:110555

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; sulfurtransferase activity; and tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness. Orthologous to human TRMU (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Zhang et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trmu Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
aminoglycoside-induced deafness	Alliance	{Deafness, mitochondrial, modifier of}	580000
transient infantile liver failure	Alliance	Liver failure, transient infantile	613070

Associated With trmu Via Experimental Models

Human Disease	Fish	Conditions	Citations
inner ear disease	trmu^{zf3047/zf3047}	standard conditions	Zhang et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR046884	tRNA-specific 2-thiouridylase MnmA-like, central domain
Domain	IPR046885	tRNA-specific 2-thiouridylase MnmA-like, C-terminal domain
Family	IPR004506	tRNA-specific 2-thiouridylase
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR023382	tRNA-specific 2-thiouridylase MnmA-like, central domain superfamily