Gene

ngly1

ID

ZDB-GENE-050522-535

Name

N-glycanase 1

Symbol

ngly1 Nomenclature History

Previous Names

im:6895151
zgc:110561 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity. Predicted to be involved in glycoprotein catabolic process; protein deglycosylation; and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in NGLY1-deficiency. Orthologous to human NGLY1 (N-glycanase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6895151 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Mesika et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ngly1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital disorder of deglycosylation 1	Alliance	Congenital disorder of deglycosylation 1	615273

Associated With ngly1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002931	Transglutaminase-like
Domain	IPR006588	Peptide N glycanase, PAW domain
Domain	IPR018997	PUB domain
Family	IPR050883	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR036339	PUB-like domain superfamily
Homologous_superfamily	IPR038680	PAW domain superfamily
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily