Gene
gfi1aa
- ID
- ZDB-GENE-050522-534
- Name
- growth factor independent 1A transcription repressor a
- Symbol
- gfi1aa Nomenclature History
- Previous Names
-
- gfi1.1
- gfi1a
- zgc:113277 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within primitive erythrocyte differentiation. Is expressed in several structures, including artery; hematopoietic cell; inner ear; lateral line system; and mesoderm. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158523 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| severe congenital neutropenia 2 | Alliance | Neutropenia, severe congenital 2, autosomal dominant | 613107 |
| ?Neutropenia, nonimmune chronic idiopathic, of adults | 607847 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myelodysplastic syndrome | gfi1aaszy5/szy5; i114Tg/i114Tg | standard conditions | Wu et al., 2021 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:Q501T1
|
385 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gfi1aa-201
(1)
|
Ensembl | 1,464 nt | ||
| mRNA |
gfi1aa-202
(1)
|
Ensembl | 1,607 nt |
Interactions and Pathways
No data available
Plasmids
No data available