Gene
gfi1aa
- ID
- ZDB-GENE-050522-534
- Name
- growth factor independent 1A transcription repressor a
- Symbol
- gfi1aa Nomenclature History
- Previous Names
-
- gfi1.1
- gfi1a
- zgc:113277 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in primitive erythrocyte differentiation. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pancreas; and sensory system. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158523 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| severe congenital neutropenia 2 | Alliance | Neutropenia, severe congenital 2, autosomal dominant | 613107 |
| ?Neutropenia, nonimmune chronic idiopathic, of adults | 607847 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myelodysplastic syndrome | gfi1aaszy5/szy5; i114Tg/i114Tg | standard conditions | Wu et al., 2021 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:Q501T1
|
385 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gfi1aa-201
(1)
|
Ensembl | 1,464 nt | ||
| mRNA |
gfi1aa-202
(1)
|
Ensembl | 1,607 nt |
Interactions and Pathways
No data available
Plasmids
No data available