Gene
gdap1
- ID
- ZDB-GENE-050522-424
- Name
- ganglioside induced differentiation associated protein 1
- Symbol
- gdap1 Nomenclature History
- Previous Names
-
- si:rp71-1m12.2
- zgc:112286
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Acts upstream of or within neuron projection development. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in central nervous system and cranial ganglion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease axonal type 2C; Charcot-Marie-Tooth disease axonal type 2K; Charcot-Marie-Tooth disease recessive intermediate A; and Charcot-Marie-Tooth disease type 4A. Orthologous to human GDAP1 (ganglioside induced differentiation associated protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112286 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gonzaga-Jauregui et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease axonal type 2K | Alliance | Charcot-Marie-Tooth disease, axonal, type 2K | 607831 |
| Charcot-Marie-Tooth disease recessive intermediate A | Alliance | Charcot-Marie-Tooth disease, recessive intermediate, A | 608340 |
| Charcot-Marie-Tooth disease type 4A | Alliance | Charcot-Marie-Tooth disease, type 4A | 214400 |
| Charcot-Marie-Tooth disease, axonal, with vocal cord paresis | 607706 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004045 | Glutathione S-transferase, N-terminal |
| Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
| Domain | IPR034336 | Ganglioside-induced differentiation-associated protein 1, C-terminal domain |
| Family | IPR040079 | Glutathione transferase family |
| Homologous_superfamily | IPR036249 | Thioredoxin-like superfamily |
| Homologous_superfamily | IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Ganglioside-induced differentiation-associated protein 1, C-terminal domain | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Glutathione S-transferase, N-terminal | Glutathione transferase family | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PXI3
|
216 | ||||||
|
UniProtKB:Q78AN2
|
362 | ||||||
|
UniProtKB:A0A8M2B9N6
|
280 |
Interactions and Pathways
No data available
Plasmids
No data available