Gene

gtpbp3

ID

ZDB-GENE-050522-335

Name

GTP binding protein 3, mitochondrial

Symbol

gtpbp3 Nomenclature History

Previous Names

zgc:112394 (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have GTP binding activity and GTPase activity. Involved in embryonic organ development. Localizes to mitochondrion. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:112394 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gtpbp3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 23	Alliance	Combined oxidative phosphorylation deficiency 23	616198

Associated With gtpbp3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
mitochondrial metabolism disease	AB + MO2-gtpbp3	standard conditions	Chen et al., 2016
hypertrophic cardiomyopathy	gtpbp3^{zf2239/zf2239} (AB)	standard conditions	Chen et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005225	Small GTP-binding domain
Domain	IPR006073	GTP binding domain
Domain	IPR018948	GTP-binding protein TrmE, N-terminal
Domain	IPR025867	MnmE, helical domain
Domain	IPR031168	TrmE-type guanine nucleotide-binding domain
Family	IPR004520	tRNA modification GTPase MnmE
Homologous_superfamily	IPR027266	GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1
Homologous_superfamily	IPR027368	tRNA modification GTPase MnmE domain 2
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	GTP binding domain	GTP-binding protein TrmE/Aminomethyltransferase GcvT, domain 1	GTP-binding protein TrmE, N-terminal	MnmE, helical domain	P-loop containing nucleoside triphosphate hydrolase	Small GTP-binding domain	TrmE-type guanine nucleotide-binding domain	tRNA modification GTPase MnmE	tRNA modification GTPase MnmE domain 2
UniProtKB:Q501Z5 InterPro	500

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gtpbp3-201 (1) Ensembl	Ensembl	1,664 nt	Select Tool ZFIN BLAST
mRNA	gtpbp3-202 (1) Ensembl	Ensembl	818 nt	Select Tool ZFIN BLAST
mRNA	gtpbp3-204 (1) Ensembl	Ensembl	1,557 nt	Select Tool ZFIN BLAST
mRNA	gtpbp3-205 (1) Ensembl	Ensembl	1,889 nt	Select Tool ZFIN BLAST
mRNA	gtpbp3-206 (1) Ensembl	Ensembl	1,344 nt	Select Tool ZFIN BLAST
ncRNA	gtpbp3-003 (1) Ensembl	Ensembl	437 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations