Gene

mlx

ID

ZDB-GENE-050522-316

Name

MAX dimerization protein MLX

Symbol

mlx Nomenclature History

Previous Names

im:7146242
TF4 (1)
wu:fb61a01
wu:fb99c01
zgc:112409

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Takayasu's arteritis. Orthologous to human MLX (MAX dimerization protein MLX).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7146242 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Weger et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mlx Human Ortholog

No data available

Associated With mlx Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Family	IPR052207	Max-like/E-box-binding transcription factors
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily